Bryan Johnson’s Plasma Replacement: The Most Extreme Longevity Biohack Yet?
Inside the full-body blood swap experiment that’s sparking debate across the anti-aging world
The Boldest Biohack Yet?
I’ve fasted. I’ve cold plunged. I’ve tracked HRV like my life depended on it.
But would I ever drain all the plasma from my body and replace it with synthetic proteins?
That’s what tech mogul and self-experimenter Bryan Johnson just did in what he’s calling "V2." As in, Version 2 of his biological self.
You read that right. Every drop of his plasma—gone. Replaced entirely with albumin, the protein-rich component that helps regulate blood volume and detox transport in the body.
So what exactly is V2? And how is it different from his earlier experiments?
🧪 V1 vs V2: Johnson’s Plasma Protocols
🔹 V1 – Young plasma infusions
In 2023, Johnson tried infusions of plasma from his teenage son. The theory (controversial, but based on parabiosis studies in mice) was that young blood might rejuvenate aging tissues.
🔹 V2 – Full plasma replacement
In 2025, he upped the ante: no donor plasma, no half-measures. Just a complete exchange of his own plasma for albumin. Think of it like wiping your internal slate clean.
🧬 The Science Behind Plasma Replacement
Plasma exchanges are not new—but they’re typically reserved for extreme medical conditions like autoimmune disorders or liver failure.
Johnson’s version? It’s elective. Experimental. Monitored closely with biomarker tracking.
Albumin carries hormones, vitamins, and waste products through the body. Replacing your plasma with purified albumin might mean fewer toxins, clearer transport channels, and potentially lower inflammation. But those are big claims without large-scale data.
Right now, there’s no clinical proof that this improves longevity.
🤔 Why Would Anyone Do This?
From a biohacker’s point of view, Johnson’s bet makes sense:
We know inflammaging—chronic, low-grade inflammation—is a core driver of aging.
Plasma is a carrier of inflammatory cytokines and oxidative stress markers.
Replacing it with “clean” albumin could theoretically reduce that burden and reset cellular signaling.
That said, most biohackers prefer safer, cheaper ways to lower inflammation: fasting, curcumin, Zone 2 training, etc.
But Johnson? He’s data-rich and risk-tolerant. He wants to be the N=1 for futuristic medicine.
💬 The Internet Reacts
Reactions to Johnson’s V2 experiment have been wild:
“He’s making his body open-source.”
“This is medical cosplay.”
“It’s expensive nonsense.”
“Or… it’s a glimpse of medicine in 2040.”
No one’s neutral. But that’s kind of the point.
If nothing else, he’s pushing the conversation forward—about how we define aging, healthspan, and what it really means to reset.
🧠 What Biohackers Can Learn
Even if full plasma replacement isn’t in your future, V2 raises smart questions:
Are your detox pathways clear and functional?
Is your inflammation under control?
What would it look like to “start fresh” metabolically?
Simple steps like supporting your liver (NAC, broccoli sprouts), reducing oxidative stress (cold exposure, C60), and maintaining hydration already help your body clean itself daily—no IV bags required.
But as always, it's about context, not just tactics.
⚠️ A Quick Note on Safety
This type of procedure is expensive, experimental, and not recommended outside supervised clinical settings.
No matter how cool a biohack seems, always prioritize:
✅ Data
✅ Safety
✅ Sustainability
Longevity is a long game, not a headline.
In Summary
Bryan Johnson’s plasma swap might sound extreme—but it’s part of a growing movement to rethink aging as a process we can influence, not just accept.
Whether you cheer him on or cringe at the cost, the bigger question is this:
What are you doing today to build your Version 2?
🧬 If you want practical, grounded ways to optimize your biology without draining your bank account (or blood supply), stick with us.
